Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class.
作者： B. Grossmann , G. Weinbauer , P. Hirschmann , P. H. Vogt
DOI: 10.1007/BF03343785
关键词:
摘要: We isolated the complete deleted-in-azoospermia-like-1 (DAZL1) gene of old world monkey Macaca fascicularis (tentatively designated as MafaDAZL1) and compared its sequence structure to that other DAZL1 genes so far. In addition homologous RNA recognition motif (RRM domain), we only identified a high conservation Mafa-DAZL1 coding region mammalian (i.e. mouse: Dazl1; human: DAZL1) Xenopus (xdazl). Only in primates, human, sequences lengths 5' 3' untranslated structures (UTRs) displayed similar their regions 91-94%). Both belong primate class monkeys evolutionarily separated 36-55 million years ago (1). The strong both species suggests control maturation pathway transcripts germ line also indicates function RNA-binding protein this class.
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