Cardiopulmonary bypass during a second-lung implantation improves postoperative oxygenation after sequential double-lung transplantation.

摘要: Objectives During sequential double-lung transplantation (DLT), the newly implanted first lung receives entire cardiac output during implantation of second one. This may be responsible for increased hydrostatic pressure that causes severe interstitial and alveolar edema can lead to allograft dysfunction. The authors tested hypothesis CPB started after graft before recipient removal should improve post-transplantation oxygenation clinical outcomes. Design Observational 2 consecutive 1-year periods. Setting University hospital. Participants Nine patients undergoing DLT with were compared controls, who 10 underwent but without year before. Measurements Main Results Oxygenation was assessed. use associated an mean postoperative ratio PaO fraction inspired oxygen at 1 hour (363±51 v 240±113, p = 0.01) 6 hours (430±111 280±103, 0.03). duration 111±19 min. occurrence primary dysfunction need extracorporeal membrane tended lower, did not reach significance. Similarly, mortality rate comparable between both groups, as blood transfusions. Conclusions authors' results suggest appears benefit reduces pulmonary in transplanted lung.