Increased plasma levels epithelial cell-derived neutrophil-activating peptide 78/CXCL5 in periodontitis patients undergoing supportive therapy

摘要: Lappin DF, Murad M, Sherrabeh S, Ramage G. Increased plasma levels epithelial cell-derived neutrophil-activating peptide 78/CXCL5 in periodontitis patients undergoing supportive therapy. J Clin Periodontol 2011; 38: 887–893. doi: 10.1111/j.1600-051X.2011.01757.x. Abstract Aim: To investigate the influence of cigarette smoking on peptide-78 (CXCL5/ENA-78) and interleukin-6 (IL-6) therapy patients. Materials Methods: Plasma concentrations CXCL5/ENA-78 IL-6 were evaluated 167 systemically healthy subjects (54 smokers 113 non-smokers) divided into four groups: non-smokers with (n=90), (n=49), non (n=23) (n=5). Results: Clinical probing depth (CPD) significantly greater than those non-smoking (p<0.05). Although clinical attachment loss (CAL) number deep sites affected periodontitis, these differences not significant. Periodontitis had higher ENA-78 There was no significant difference between but (p=0.006). correlated CPD, CAL tobacco consumption (all p<0.05). Conclusion: are a good systemic indicator inflammatory process disease severity addition potential effects smoking. Further studies required to elucidate biological mechanisms underlining this increase