Stochastic Collective Movement of Cells and Fingering Morphology: No Maverick Cells

摘要: The classical approach to model collective biological cell movement is through coupled nonlinear reaction-diffusion equations for cells and diffusive chemicals that interact with the cells. This takes into account diffusion of cells, proliferation, death chemotaxis. Whereas has many advantages, it fails consider factors affect multicell movement. In this work, a multiscale approach, Glazier-Graner-Hogeweg model, used. implemented finite element method chemical. state as discrete allows include cohesive forces between deformation following path single cell, stochastic behavior Where continuity tissue at epidermis violated, regenerate skin heal wound. We assume secrete chemical when they feel wounded region are attracted by release (chemotaxis). Under certain parameters, front encounters fingering morphology, two fronts progressing against each other correlated. Cell flow exhibits interesting patterns, drift effect on may influence cells' motion. effects polarized substrate also discussed.