Pregnancy outcomes in females after treatment for childhood cancer.

摘要: This Ontario province-wide cohort study was conducted to compare the risk of adverse pregnancy outcomes in female childhood cancer survivors who received abdominal-pelvic radiation and/or chemotherapy with alkylating agents among those were treated by non-sterilizing surgery only. Females Ontario, Canada, diagnosed 1964-1988 before age 20 a histologically confirmed malignancy and had survived for at least 5 years, attained 18, alive time study, identified through Cancer Registry. We ascertained telephone-administered questionnaire. Treatment data abstracted from medical records 830 subjects 18-49 years age, analysis comprised 340 one or more pregnancies after treatment. There no evidence an increased having spontaneous abortion infant birth defect. Survivors receiving likely have low weight (odds ratio estimate [OR] = 3.64; 95% confidence interval [CI] 1.33-9.96), premature (OR 3.29; CI 0.97-11.1), died perinatal period 2.41; 0.50-11.5), compared surgery. Risks death dose radiotherapy directed abdomen.