Characterization of the plant homologue of prohibitin, a gene associated with antiproliferative activity in mammalian cells.
作者： Wayne A. Snedden , Hillel Fromm*
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摘要: This report describes the cloning and characterization of a plant cDNA coding for protein which shows high amino acid sequence similarity with prohibitin, whose gene is associated antiproliferative activity in mammalian cells. Arabidopsis thaliana Nicotiana tabacum prohibitin complete cDNAs were isolated, expression pattern was examined using polyclonal antibodies raised against recombinant expressed Escherichia coli. A single immunoreactive detected various species all organs examined. Subcellular fractionation tobacco leaves revealed mitochondrial-enriched fraction. Phylogenetic conservation prohibitin's subcellular localization suggests similar function plants, yeast mammals.
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