Methicillin-Resistant Staphylococcus aureus Central Line–Associated Bloodstream Infections in US Intensive Care Units, 1997-2007

摘要: Context Concerns about rates of methicillin-resistant Staphylococcus aureus (MRSA) health care–associated infections have prompted calls for mandatory screening or reporting in efforts to reduce MRSA infections. Objective To examine trends the incidence central line–associated bloodstream (BSIs) US intensive care units (ICUs). Design, Setting, and Participants Data reported by hospitals Centers Disease Control Prevention (CDC) from 1997-2007 were used calculate pooled mean annual BSI 7 types adult non-neonatal pediatric ICUs. Percent was defined as proportion S BSIs that MRSA. We regression modeling estimate percent changes metrics over analysis period. Main Outcome Measures Incidence rate per 1000 line days; among BSIs. Results Overall, 33 587 1684 ICUs representing 16 225 498 patient-days surveillance; 2498 (7.4%) 1590 (4.7%) methicillin-susceptible (MSSA). Of evaluated ICU types, surgical, nonteaching-affiliated medical-surgical, cardiothoracic, coronary experienced increases 1997-2001 period; however, medical, teaching-affiliated no significant changes. From 2001 through 2007, declined significantly all except units, which remained static. Declines ranged −51.5% (95% CI, −33.7% −64.6%; P  Conclusions The has been decreasing recent years most CDC. These are not apparent when only is monitored.