Modeling Parkinson's disease in the common marmoset (Callithrix jacchus): overview of models, methods, and animal care.

摘要: The common marmoset (Callithrix jacchus) is a small-bodied, popular New World monkey and used widely in reproductive biology, neuroscience, drug development, due to its comparative ease of handling, high efficiency, unique behavioral characters. In this review, we discuss the models Parkinson’s disease (PD), which neurological movement disorder primarily resulting from degeneration dopaminergic neurons with clinical features tremor, rigidity, postural instability, akinesia. most PD involve administration 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine study pathogenesis evaluate novel therapies. Following systemic local these neurotoxins, marmosets very severe symptoms are recommended be placed an intensive care unit artificial feeding increase survival rate. All procedures MPTP should conducted special room enclosed cages under negative-pressure by trained researchers personal protection. Behavioral tests provide external measure brain pathology. Along several biomarkers, including α-synuclein DJ-1, non-invasive neuroimaging techniques such as positron emission tomography magnetic resonance imaging functional changes associated PD. With recent growing interest potential therapies stem cell gene therapy for Korea, can considered suitable non-human primate model research bridge gap between rodent studies applications.