Treatment with telmisartan attenuates graft arteriosclerosis in murine cardiac allografts
作者： Hisanori Kosuge , Takashi Ishihara , Go Haraguchi , Yasuhiro Maejima , Hiroyuki Okada
DOI: 10.1016/J.HEALUN.2009.11.001
关键词:
摘要: Background Chronic rejection remains the most prominent cause of graft failure after transplantation. Recently, it was reported that telmisartan can function as a partial agonist peroxisome proliferator-activated receptor γ (PPARγ) in addition to blocker angiotensin II receptor. We investigated effect on chronic rejection. Methods Hearts from Bm12 mice were transplanted into C57BL/6 (Class mismatch), and allografts harvested at 8 weeks Recipient fed either control chow or containing (10 mg/kg/day) 1 day before Proliferation assays smooth muscle cells (SMCs), which isolated aorta B/6 mice, performed. Results Although severe neo-intimal hyperplasia developed (luminal occlusion 70.9 ± 6.1%), significantly attenuated (30.0 10%, p Conclusions Telmisartan attenuates SMC proliferation via PPARγ activity suppresses may be useful for suppressing allograft
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