Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational population-based study

摘要: Summary Background Young people (aged 0–18 years) have been disproportionately affected by pandemic influenza A H1N1 infection. We aimed to analyse paediatric mortality inform clinical and public health policies for future seasons pandemics. Methods All deaths related infection from June 26, 2009, March 22, 2010 in England were identified through daily reporting systems cross-checking of records validated confirmation laboratory results or death certificates. Clinicians responsible each individual child provided detailed information about past medical history, presentation, course the acute illness. Case estimates obtained Health Protection Agency. The primary outcome measures population rates case-fatality rates. Findings 70 reported. Childhood rate was 6 per million population. highest children aged less than 1 year. Mortality higher Bangladeshi (47 [95% CI 17–103]) Pakistani (36 [18–64]) white British (4 [3–6]). 15 (21%) who died previously healthy; 45 (64%) had severe pre-existing disorders. age-standardised a disorder chronic neurological disease (1536 population). 19 (27%) occurred before inpatient admission. Children this subgroup significantly more likely healthy only mild disorders those after admission (p=0·0109). Overall, received oseltamivir: seven within 48 h symptom onset. Interpretation Vaccination priority should be at increased risk illness influenza. This group might include with specified some ethnic minority groups. Early pre-hospital supportive therapeutic care is also important. Funding Department Health, UK