Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany.

摘要: Autopsies of deceased with a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can provide important insights into the novel disease and its course. Furthermore, autopsies are essential for correct statistical recording 2019 (COVID-19) deaths. In northern German Federal State Hamburg, all deaths Hamburg citizens ante- or postmortem PCR-confirmed SARS-CoV-2 have been autopsied since outbreak pandemic in Germany. Our evaluation provides systematic overview first 80 consecutive full autopsies. A proposal categorisation is presented (category 1: definite COVID-19 death; category 2: probable 3: possible death an equal alternative cause 4: detection not associated to COVID-19). six cases, was diagnosed by positive PCR test nasopharyngeal lung tissue swab. other 74 had already known antemortem. The were aged between 52 96 years (average 79.2 years, median 82.4 years). study cohort, 34 female (38%) 46 male (62%). Overall, 38% overweight obese. All deceased, except two women, whom no significant pre-existing conditions found autoptically, relevant comorbidities (in descending order frequency): (1) diseases cardiovascular system, (2) diseases, (3) central nervous system (4) kidney (5) diabetes mellitus. total 76 cases (95%) classified as deaths, corresponding categories 1-3. Four (5%) defined non-COVID-19 virus-independent causes death. eight pneumonia combined fulminant pulmonary artery embolism. Peripheral embolisms nine cases. deep vein thrombosis has 40% This largest SARS-CoV-2-infected patients so far.