The Hpk2-Rrp2 two-component regulatory system of Treponema denticola: a potential regulator of environmental and adaptive responses.

摘要: Treponema denticola levels in the gingival crevice become elevated as periodontal disease develops. Oral treponemes may account for much 40% of total bacterial population pocket. The stimuli that trigger enhanced growth T. denticola, and mechanisms associated with transmission these signals, remain to be defined. We hypothesize open reading frames tde1970 (histidine kinase) tde1969 (response regulator) constitute a functional two-component regulatory system regulates, at least part, responses changing environmental conditions development disease. results presented demonstrate are conserved, universal among isolates transcribed part seven-gene operon growth-phase-dependent manner. undergoes autophosphorylation transfers phosphate tde1969. Henceforth, proteins encoded by designated Hpk2 Rrp2 respectively. kinetics were influenced presence or absence PAS domain. It can concluded contributes sensing.