作者: L. Lauren Beck , Todd G. Smith , Timothy R. Hoover
DOI: 10.1016/J.TIM.2007.09.008
关键词:
摘要: Transcriptional activation in bacteria usually involves an activator protein that binds to sites near the target promoter. Some activators of σ 54 -RNA polymerase holoenzyme, however, can stimulate transcription even when their DNA-binding domains are removed. Recent studies have revealed examples -dependent naturally lack and seem activate from solution rather than specific DNA sites. In addition, some function with other forms RNA including Bacillus subtilis Spx bacteriophage N4 single-stranded protein, also without binding DNA. Because regulatory enables promoters, alternative strategies for achieving specificity required do not bind