Nerve growth factor treatment of adult rats selectively enhances innervation of urinogenital tract rather than vascular smooth muscle

摘要: Abstract Following treatment of adult rats with nerve growth factor (0.5 mg/rat, three times a week for 3 weeks), the innervation cardiovascular and urinogenital tract smooth muscle was investigated using immunoassay immunohistochemical techniques. Substance P calcitonin gene-related peptide levels were increased in vas deferens, but not atria or femoral artery. Neuropeptide Y vasoactive intestinal polypeptide unchanged. In penile tissues, there marked increase density substance P-, peptide-, neuropeptide Y-, tyrosine hydroxylase- polypeptide-containing nerves innervating urethra SP-containing tunica little change deep dorsal vein artery corpus cavernosum. bladder, detrusor by Y- nerves, decrease P-containing trigone. There no changes after treatment. Thus, mature rat, sensory sympathetic appear to be more responsive exogenous than those muscle. This may reflect an ongoing requirement plasticity sexually animal.