Progressive changes in adrenergic, serotonergic, and peptidergic nerves in proximal colon of streptozotocin-diabetic rats

摘要: The effect of progression diabetes on adrenergic, serotonergic, and peptidergic innervation the proximal colon rat at 8, 16, 25 wk after induction with streptozotocin was investigated using immunohistochemical, biochemical, immunochemical methods. Two different responses to emerged from present study. first response, which involves noradrenaline vasoactive intestinal peptide, characterized by a sign degeneration, where there an initial increase in tissue level immunoreactivity transmitters followed decrease density nerve fibers 16 diabetes. second 5-hydroxytryptamine, substance P, calcitonin gene-related changes no evidence degeneration. third feature one resistance change due diabetes, demonstrated neuropeptide Y-containing nerves, neither Y nor immunoreactivity. It seems likely that overall described will have profound implications function gut streptozotocin-diabetic model may some parallels diabetic humans.