Colonization of adrenal glands and ovaries of mice by HSV-2 variants. I. Virological studies.

摘要: HSV-2 strain ER was shown to consist of variants with different pathogenic phenotype: Variant ER+ replicates high titers in the adrenal glands and ovaries but much less spleen; testes were not colonized. migrates spinal ganglia is highly neuroinvasive after i.p. inoculation. ER- 100-1,000 fold ovaries, proceeds without invading CNS. However, both are neuropathogenic direct i.c. injection. We conclude that neuropathogenicity, neuroinvasiveness ability replicate as well each determined by sets genes. Replication mouse embryo fibroblasts--but Vero adreno cortical carcinoma Y1 cells--is for strains. Also adsorption capacity cultured cells differs addition D.S. 500. eliminated from blood stream more quickly than ER+. Finally, C. parvum reduces rate replication ovaries. It concluded replications rates cell types critical spread HSV responsible pathobiological properties.