Comparison of intravenous and topical lidocaine as a suppressant of coughing after bronchoscopy during general anesthesia.

摘要: Twenty-four consecutive patients scheduled for fiberbronchoscopy were randomized to receive double-blind either intravenous (1.5 mg/kg) or laryngotracheal (3 lidocaine evaluate the influence on post-bronchoscopic laryngospasm, pain in throat and coughing. Plasma concentrations analyzed 5, 15, 30 60 min after administration. None of demonstrated laryngospasm during first hour bronchoscopy. Patients receiving topical coughed significantly more than lidocaine, with a median number coughs 20 compared 4, (P less 0.01). The plasma higher administration 0.001). After exceeded accepted level potential toxicity five out 11 patients, but none developed toxic symptoms no side-effects observed.