Prophylactic Versus Therapeutic Administration of Intravenous Lidocaine for Suppression of Post-extubation Cough Following Cataract Surgery: A Randomized Double Blind Placebo Controlled Clinical Trial

摘要: Background: Post-extubation cough causes considerable patient discomfort and in certain surgical procedures may lead to postoperative complication. Different drugs techniques have been used for the prevention of post-extubation with variable success rates. Prophylactic administration lidocaine has tried controversial results. No previous study performed evaluate therapeutic effect intravenous treatment cough. This was designed compare prophylactic that a sample adult patients undergoing general anesthesia cataract surgery. Methods: The two phases. In first phase 200 were consecutively included study. They randomly divided into groups receive either 1mg/kg or same volume normal saline as placebo prior extubation. Proportions compared between groups. Patients established comprised second which they 0.5mg/kg abort coughs. successful response Results: not significantly different revealed by 19(20.7%) vs. 27 (28.7%) placebo. efficacy suppression estimated be 28.1%. Proportion who successfully treated higher group 20 (80%) 10 (38.5%) (P=0.003). Conclusions: outcome this shows tracheal extubation ineffective prevent Based on results it can recommended should upon occurrence instead routine lidocaine.