Is intravenous lidocaine an effective adjuvant for endotracheal intubation in children undergoing induction of anesthesia with halothane-nitrous oxide?

摘要: Abstract Study Objective: To evaluate the efficacy of intravenous (IV) lidocaine in suppressing cough reflex and increases intraocular pressure (IOP), heart rate (HR), mean arterial (MAP) elicited by endotracheal intubation. Design: Prospective, randomized, placebo-controlled, blinded study. Patients: 60 ASA physical status I premedicated children aged 2 to 6 years undergoing induction anesthesia with halothane-nitrous oxide (N O) for surgery correct strabismus. Interventions: Patients were randomly divided into two groups 30 each. The control group (C) received saline treatment (L) mg/kg IV 90 seconds prior Measurements Main Results: Awake HR MAP; IOP, HR, MAP 45 intubation, immediately after 1 minute later, recorded. Coughing was noted at Lidocaine prevented coughing a significant increase IOP. Although observed both (comparing preintubation postintubation values), these significantly less L compared C group. Conclusions: In healthy children, years, who are halothane-N O, given laryngoscopy effectively suppresses IOP secondary intubation attenuates MAP.