Effects of graded doses of propofol for anesthesia induction on cardiovascular parameters and intraocular pressures in normal dogs.

摘要: Abstract Objective To determine the effects of graded doses propofol on cardiovascular parameters and intraocular pressures (IOP) in normal dogs. Study design Prospective, randomized, modified Latin square, cross-over experimental study. Animals Eleven adult random-source dogs weighing 20.2 ± 5.7 kg. Methods There were three treatment groups: 8 mg kg −1 intravenous (IV) until loss jaw tone (Group P), +20% P20), +50% P50). Atracurium 0.1 IV was administered all treatments immediately after propofol. All received a randomized order, with at least one week interval between treatments. Direct arterial blood pressure IOP by applanation tonometry obtained baseline, 5 minutes pre-oxygenation (before induction), before, intubation. Blood gas samples pre-oxygenation, before Results no significant difference readings any time point among groups. The significantly higher intubation versus induction smaller change systolic, mean (MAP), diastolic (DAP) P50 group compared P MAP DAP P20 increase CO 2 from to greater than or Conclusions clinical relevance Graded did not affect observed Higher are apparent additional benefit animals who cannot tolerate an abrupt but may be accompanying orotracheal