Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane

摘要: Abstract Study Objective To investigate whether the type of anesthetic agent administered affects antitussive effect remifentanil. Design Prospective randomized study. Setting Operating room a university hospital. Patients 78 ASA physical status 1 and 2 women, aged 20 to 65 years, who were scheduled undergo thyroidectomy. Interventions randomly assigned three groups receive anesthesia with propofol (Group P), sevoflurane S), or desflurane D). The main anesthetics titrated maintain target Bispectral Index for hypnosis 40 60. Remifentanil was via effect-site target-controlled infusion (TCI). determine effective remifentanil concentration (Ce) suppress coughing in each group, up-and-down sequential allocation design used. Measurements half maximal (EC 50 ) values preventing estimated using isotonic regression compared among groups. Main Results EC cough suppression Group P [1.60 ng/mL (98.3% CI, 0.92 - 1.75 ng/mL)] statistically lower than D [1.96 1.81 2.50 ng/mL)]. S 1.39 2.13 ng/mL), which higher D, but did not differ significantly from either group. Conclusions administration during emergence should be customized agent.