Effects of human chorionic gonadotropin and progesterone on follicular development in the immature rat.
作者： JoANNE S. RICHARDS , KATRYNA BOGOVICH
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摘要: To determine if small sustained increases in serum LH (hCG) activity can stimulate the maturation of antral follicles intact prepubertal rats, 24- or 29-day-old animals were injected twice daily for 2 days with 0.15 IU hCG. Functional changes follicular cells determined by measuring granulosa and thecal cell LH/hCG receptor content, arornatase activity, endogenous estradiol production, hormonally responsive progesterone accumulation, prostaglandin adenylate cyclase vitro. Each these components activities increased progressively after administration hCG vivo. A bolus injection 5 induced ovulation low dose hCGtreated animals, an average 11 ovulations/rat, indicating that preovulatory had developed. physiological concentrations have effect on responsiveness to hCG, implants (delivering 50–70 ng/m...
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