Bronchodilators in chronic air-flow limitation: effects on airway function, exercise capacity, and quality of life

摘要: We conducted a trial of inhaled salbutamol and orally administered theophylline in patients whose acute response to was less than 25% their baseline FEV1. Patients underwent 4 treatment periods, each 2 wk duration, during which they received the following combinations: placebo-placebo, placebo-salbutamol, placebo-theophylline, salbutamol-theophylline. The 19 patient who completed study were all males with mean age 65 +/- 7.4 yr, FEV1 1.02 0.38, VC 2.73 0.19. Outcomes included twice-daily recordings peak flow rates, spirometry, distance could walk 6 min, clinical symptoms dyspnea, fatigue, emotional function. Clinically important statistically significant differences between periods noted on both physiologic functional outcomes. For group as whole, improvement comparable, additional benefit gained from combination drugs. conclude that can improve airflow obstruction, exercise capacity, quality life primarily fixed air-flow limitation.