Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells.
作者： Hideo Yagita , Hisaya Akiba , Nobuhiko Kayagaki , Haruki Okamura , Kenji Nakanishi
DOI:
关键词:
摘要: TNF-related apoptosis-inducing ligand (TRAIL), a new member of TNF family, induces apoptotic cell death various tumor cells. We recently showed that TRAIL mediates perforin- and Fas (FasL)-independent cytotoxic activity human CD4+ T clones. In the present study, we investigated expression function on murine lymphocytes by using newly generated anti-murine mAbs. Although freshly isolated T, B, or NK cells did not express detectable level their surface, remarkable was induced preferentially CD3- NK1.1+ after stimulation with IL-2 IL-15. contrast, IL-18, whereas it efficiently potentiated lymphokine-activated killer addition to perforin inactivation neutralization FasL anti-FasL mAb, anti-TRAIL mAb needed for complete inhibition IL-2- IL-15-activated cytotoxicity against mouse fibrosarcoma L929 target cells, which were susceptible both TRAIL. These results indicated preferential its potential involvement in activity.
elsevier.com
jimmunol.org 参考文章(50)
A J Darmon, N Ehrman, A Caputo, J Fujinaga, R C Bleackley, The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme. Journal of Biological Chemistry. ,vol. 269, pp. 32043- 32046 ,(1994) , 10.1016/S0021-9258(18)31596-5
H Okamura, K Nakanishi, H Tsutsui, K Higashino, K Matsui, Y Miyazawa, K Kaneda, IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. Journal of Immunology. ,vol. 157, pp. 3967- 3973 ,(1996)
Haruki Okamura, Hiroko Tsutsui, Shin-Ichiro Kashiwamura, Tomohiro Yoshimoto, Kenji Nakanishi, INTERLEUKIN-18: A NOVEL CYTOKINE THAT AUGMENTS BOTH INNATE AND ACQUIRED IMMUNITY Advances in Immunology. ,vol. 70, pp. 281- 312 ,(1998) , 10.1016/S0065-2776(08)60389-2
Eckhard R Podack, Julie Spielman, Richard K. Lee, Kristin J. Olsen, Dong Yan Zhao, Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells. Journal of Immunology. ,vol. 157, pp. 1919- 1925 ,(1996)
Giorgio Trinchieri, Biology of natural killer cells. Advances in Immunology. ,vol. 47, pp. 187- 376 ,(1989) , 10.1016/S0065-2776(08)60664-1
N Kayagaki, T Moriyama, K Ando, H Yagita, T Kaneko, M Imawari, K Okumura, Y Muto, K Hiroishi, Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL. Journal of Immunology. ,vol. 158, pp. 5283- 5291 ,(1997)
Kouetsu Ogasawara, Shigeaki Hida, Nazli Azimi, Yutaka Tagaya, Takeo Sato, Taeko Yokochi-Fukuda, Thomas A. Waldmann, Tadatsugu Taniguchi, Shinsuke Taki, Requirement for IRF-1 in the microenvironment supporting development of natural killer cells Nature. ,vol. 391, pp. 700- 703 ,(1998) , 10.1038/35636
Hideo Yagita, Hisaya Akiba, Nobuhiko Kayagaki, Akemi Kawasaki, Ko Okumura, Masafumi Nakayama, Noriko Yamaguchi, Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity Journal of Immunology. ,vol. 162, pp. 2639- 2647 ,(1999)
A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L. S. Park, D. M. Anderson, J. G. Giri, S. Kumaki, M. Ahdieh, D. J. Friend, Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. The EMBO Journal. ,vol. 14, pp. 3654- 3663 ,(1995) , 10.1002/J.1460-2075.1995.TB00035.X
S Yonehara, T Kataoka, N Shinohara, H Takayama, K Takaku, K Nagai, S Kondo, Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Journal of Immunology. ,vol. 156, pp. 3678- 3686 ,(1996)