Comparison of the Abbott m2000 HIV-1 Real-Time and Roche AMPLICOR Monitor v1.5 HIV-1 assays on plasma specimens from Rakai, Uganda.
作者： I Ssebugenyi , A Kizza , B Mpoza , G Aluma , I Boaz
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摘要: The need for viral load (VL) monitoring of HIV patients receiving antiretroviral therapy (ART) in resource-limited settings (RLS) has become apparent with studies showing the limitations immunological monitoring. We compared Abbott m2000 Real-Time (Abbott) HIV-1 assay Roche AMPLICOR Monitor v1.5 (Roche) over a range VL concentrations. Three hundred and eleven plasma samples were tested, including 164 from on ART ≥ six months 147 ART-naive patients. detected ≥400 copies/mL 158 (50.8%) samples. Of these, produced 145 (91.8%) detectable results copies/mL; 13 (8.2%) discrepant results. Concordance between assays detecting RNA was 95.8% (298/311). sensitivity, specificity, positive predictive value negative to detect 91.8%, 100%, 100% 92.2%, respectively. For 151 bo...
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