Azines and Azoles: CXX. Synthesis of Acyclic Analogs of N1-Ribosides of Barbituric Acid and Its 5-ylidene Derivatives
作者： E. P. Studentsov , A. N. Kokhanovskii , M. B. Ganina , N. I. Nikolaeva , E. V. Fedorova
DOI: 10.1023/B:RUGC.0000025513.88248.94
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摘要: The reaction of 2,4,6-tris(trimethylsiloxy)pyrimidine with 2-oxabutane-1,4-diyl diacetate in methylene chloride the presence SnCl4 proceeds regioselectively to form 1-[(2-acetoxyethoxy)methyl]barbituric acid. latter is readily deacetylated a free acyclic analog N-ribosides barbituric 1-[(2-Acetoxy- and 2-hydroxyethoxy)methyl]barbituric acids easily react aromatic heterocyclic aldehydes water organic solvents, forming 5-ylidenebarbituric acids. structure products was proved by 1H NMR UV spectroscopy. Certain exhibit moderate antimicrobial antiviral activity.
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