A simple approach towards the synthesis of oxadeazaflavines

摘要: Abstract The synthesis of oxadeazaflavine (2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione) derivatives (1a, 1b and 1c) from barbituric acid salicylaldehydes as starting materials was shown to be possible using water solvent at room temperature. orange intermediate formed, an anthocyanidin-like precursor the desired products, gave reasonable yields oxadeazaflavines when treated with acetic acid-acetic anhydride mixture. When reaction carried out 100°C corresponding 1,5-dihydro-5(5′-barbituryl)-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-diones (4a, 4b 4c) were obtained. nitrosalicylaldehydes, either 25 or 100°C, leads only arylidenebarbituric acids.