Copper-mediated pyrazole synthesis from 2,3-allenoates or 2-alkynoates, amines and nitriles
作者： Bo Chen , Can Zhu , Yang Tang , Shengming Ma
DOI: 10.1039/C4CC02856B
关键词:
摘要: An efficient copper-mediated three-component reaction of 2,3-allenoates or 2-alkynoates, amines, and nitriles affording fully substituted pyrazoles with a very nice diversity has been developed. A tandem conjugate addition, 1,2-addition, N-N bond formation mechanism proposed for this diverse synthesis based on mechanistic studies.
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