A versatile synthesis of 2-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones
作者： Karolien Van Rompaey , Isabelle Van den Eynde , Norbert De Kimpe , Dirk Tourwé
DOI: 10.1016/S0040-4020(03)00583-0
关键词:
摘要: A mild and general strategy for the synthesis of 2-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones is described. The seven-membered lactam prepared by intramolecular amide bond formation from intermediate amino acid, which obtained either reductive alkylation a variety amines with N-Boc,N-Me-ortho-formyl-Phe Phth-ortho-formyl-Phe, or amination aldehydes N-Boc-ortho-aminomethyl-Phe.
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