Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

摘要: Background: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying observed comorbidities are unknown. Shared genetic etiology a plausible explanation for overlap, and this study we tested whether variation major histocompatibility complex (MHC), which associated risk also depression. Methods: We fine-mapped classical MHC (chr6: 29.6–33.1 Mb), imputing 216 human leukocyte antigen (HLA) alleles 4 complement component (C4) haplotypes studies from Psychiatric Genomics Consortium Major Depressive Disorder Working Group UK Biobank. total sample size was 45,149 cases 86,698 controls. association between status imputed variants, applying both region-wide significance threshold (3.9 × 10−6) candidate (1.6 10−4). Results: No HLA or C4 were at threshold. HLA-B*08:01 modest protection testing genes meta-analysis (odds ratio = 0.98, 95% confidence interval 0.97–0.99). Conclusions: found no evidence that an increased conferred by alleles, play role susceptibility to haplotypes, strongly schizophrenia. These results suggest any variants either rare have very effect sizes.