Environmental epidemiology and risk factors for autoimmune disease.

摘要: It has long been recognized that environmental influences play an important role in the risk of developing chronic rheumatic disease. Defining specific pathogenic mediators may trigger development or progression autoimmune disease remains a focus increasing investigative effort. Factors promoting not be identical to factors influence severity disorder. Human monozygotic twin studies, animal and genetic models demonstrate strongly determine whether one will develop autoimmunity, however, genes affecting metabolism exogenous agents expression have only recently drawn attention. In this article authors review recent reports advance our understanding previously challenge accepted beliefs increased estrogenic exposures predate incidence disorders, systemic lupus erythematosus particular.