Are human endogenous retroviruses triggers of autoimmune diseases? Unveiling associations of three diseases and viral loci
作者： Bjørn A. Nexø , Palle Villesen , Kari K. Nissen , Hanne M. Lindegaard , Peter Rossing
DOI: 10.1007/S12026-015-8671-Z
关键词:
摘要: Autoimmune diseases encompass a plethora of conditions in which the immune system attacks its own tissue, identifying them as foreign. Multiple factors are thought to contribute development response self, including differences genotypes, hormonal milieu, and environmental factors. Viruses human endogenous retroviruses have long been linked occurrence autoimmunity, but never proven be causative Endogenous viruses retroviral sequences embedded host germline DNA transmitted vertically through successive generations Mendelian manner. In this study by means genetic epidemiology, we searched for involvement three selected autoimmune diseases: multiple sclerosis, type 1 diabetes mellitus, rheumatoid arthritis. We found that at least one locus was associated with each diseases. Although there significant overlap, most loci only occurred studied disease. Remarkably, within disease, statistical interaction (synergy) between two loci. Additional synergy lymphocyte antigens is reported sclerosis. speculate possibility recombinants or mixed viral particles formed resulting stimulate innate system, thereby initiating response.
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