Mitochondrial dna damage as a predictor of coronary atherosclerotic heart disease
作者： Marschall S. Runge , Scott W. Ballinger , Bennett VanHouten
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摘要: The present invention demonstrates that mitochondrial DNA damage occurs prior to, or simultaneous with, atherosclerotic lesion development, aortic increases with age, and genotype diet both influence the level of damage. Hence, early in atherosclerosis, may be an initiating event atherogenesis, provides methods to predict coronary heart disease based upon amount
lens.org参考文章(48)
Bennett Van Houten, Method to detect DNA damage and measure DNA repair rate ,(1996)
T. Glen Bouder, Scott W. Ballinger, Stephen A. Judice, Richard J. Albertini, Janice A. Nicklas, Gerald S. Davis, Mitochondrial Genome Damage Associated with Cigarette Smoking Cancer Research. ,vol. 56, pp. 5692- 5697 ,(1996)
Enrique Cadenas, Kelvin J.A. Davies, Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us. Free Radical Biology and Medicine. ,vol. 29, pp. 222- 230 ,(2000) , 10.1016/S0891-5849(00)00317-8
Y Zhang, O Marcillat, C Giulivi, L Ernster, K J Davies, The oxidative inactivation of mitochondrial electron transport chain components and ATPase. Journal of Biological Chemistry. ,vol. 265, pp. 16330- 16336 ,(1990) , 10.1016/S0021-9258(17)46227-2
C J Doersen, C Guerrier-Takada, S Altman, G Attardi, Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity. Journal of Biological Chemistry. ,vol. 260, pp. 5942- 5949 ,(1985) , 10.1016/S0021-9258(18)88920-7
T.F. Slater, Barbara Sawyer, Ursula Sträuli, STUDIES ON SUCCINATE-TETRAZOLIUM REDUCTASE SYSTEMS. III. POINTS OF COUPLING OF FOUR DIFFERENT TETRAZOLIUM SALTS. Biochimica et Biophysica Acta. ,vol. 77, pp. 383- 393 ,(1963) , 10.1016/0006-3002(63)90513-4
F. M. Yakes, B. Van Houten, Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 514- 519 ,(1997) , 10.1073/PNAS.94.2.514
Gino A. Cortopassi, Norman Arnheim, Detection of a specific mitochondrial DNA deletion in tissues of older humans Nucleic Acids Research. ,vol. 18, pp. 6927- 6933 ,(1990) , 10.1093/NAR/18.23.6927
J Sastre, F V Pallardó, R Plá, A Pellín, G Juan, J E O'Connor, J M Estrela, J Miquel, J Viña, Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes Hepatology. ,vol. 24, pp. 1199- 1205 ,(1996) , 10.1002/HEP.510240536
Joel G. Fletcher, Kathleen K. S. Hui, Eric T. Fossel, Christine L. Zanella, Cell death induced by peroxidized low-density lipoprotein: endopepsis. Cancer Research. ,vol. 54, pp. 1240- 1248 ,(1994)