Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs.

作者: Xingyue Ji , Zhixiang Pan , Bingchen Yu , Ladie Kimberly De La Cruz , Yueqin Zheng

DOI: 10.1039/C8CS00395E

关键词:

摘要: … TPP moiety, which would help enrichment in mitochondria. Then cancer cells were treated with a … Such results further confirmed enrichment-triggered release in mitochondria. The same …

参考文章(114)
Yueqin Zheng, Xingyue Ji, Bingchen Yu, Kaili Ji, David Gallo, Eva Csizmadia, Mengyuan Zhu, Manjusha Roy Choudhury, Ladie Kimberly C. De La Cruz, Vayou Chittavong, Zhixiang Pan, Zhengnan Yuan, Leo E. Otterbein, Binghe Wang, Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide Nature Chemistry. ,vol. 10, pp. 787- 794 ,(2018) , 10.1038/S41557-018-0055-2
Xingyue Ji, Binghe Wang, Strategies toward Organic Carbon Monoxide Prodrugs Accounts of Chemical Research. ,vol. 51, pp. 1377- 1385 ,(2018) , 10.1021/ACS.ACCOUNTS.8B00019
Julian Tu, Minghao Xu, Saba Parvez, Randall T. Peterson, Raphael M. Franzini, Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. Journal of the American Chemical Society. ,vol. 140, pp. 8410- 8414 ,(2018) , 10.1021/JACS.8B05093
Kevin Neumann, Alessia Gambardella, Annamaria Lilienkampf, Mark Bradley, Tetrazine-mediated bioorthogonal prodrug–prodrug activation Chemical Science. ,vol. 9, pp. 7198- 7203 ,(2018) , 10.1039/C8SC02610F
Qingxin Yao, Feng Lin, Xinyuan Fan, Yanpu Wang, Ye Liu, Zhaofei Liu, Xingyu Jiang, Peng R. Chen, Yuan Gao, Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems. Nature Communications. ,vol. 9, pp. 5032- ,(2018) , 10.1038/S41467-018-07490-6
Zhuzhou Shao, Wei Liu, Huimin Tao, Fang Liu, Ruxin Zeng, Pier Alexandre Champagne, Yang Cao, K. N. Houk, Yong Liang, Bioorthogonal release of sulfonamides and mutually orthogonal liberation of two drugs. Chemical Communications. ,vol. 54, pp. 14089- 14092 ,(2018) , 10.1039/C8CC08533A
Michel Azoulay, Gérald Tuffin, Wafa Sallem, Jean-Claude Florent, A new drug-release method using the Staudinger ligation. Bioorganic & Medicinal Chemistry Letters. ,vol. 16, pp. 3147- 3149 ,(2006) , 10.1016/J.BMCL.2006.03.073
Kenneth J. Shea, Jang Seob Kim, Influence of strain on chemical reactivity. Relative reactivity of torsionally strained double bonds in 1,3-dipolar cycloadditions Journal of the American Chemical Society. ,vol. 114, pp. 4846- 4855 ,(1992) , 10.1021/JA00038A059
Yueqin Zheng, Xingyue Ji, Kaili Ji, Binghe Wang, Hydrogen sulfide prodrugs-a review. Acta Pharmaceutica Sinica B. ,vol. 5, pp. 367- 377 ,(2015) , 10.1016/J.APSB.2015.06.004