Two-component system regulon plasticity in bacteria: a concept emerging from phenotypic analysis of Yersinia pseudotuberculosis response regulator mutants.

摘要: In bacteria, the most rapid and efficient means of adapting gene transcription to extracellular stresses often involves sophisticated systems referred as two-component (2CSs). Although highly conserved throughout bacterial world, some these may control distinct cell events have differing contributions virulence, depending on species considered. This chapter summarizes work performed by our group--from initial PhoP-PhoQ PmrA-PmrB studies recent genome-scale preliminary analyses--in an attempt highlight contribution 2CS regulon plasticity acquisition Yersinia pseudotuberculosis' specific features.