Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and α-chymotrypsin
作者： Gabriela Paun , Simona Carmen Litescu , Elena Neagu , Andreia Tache , Gabriel Lucian Radu
DOI: 10.3109/14756366.2012.749399
关键词:
摘要: This study was meant to determine the inhibitory activity of tannins and flavonoid compounds from Geranium robertianum, Helleborus purpurascens Hyssopus officinale plant polyphenol rich extracts against urease α-chymotrypsin. The G. H. were purified concentrated by microfiltration ultrafiltration. Phenolic including flavonoids have been linked many pharmacological activities. Thus, polyphenolic content assessed UV-Vis spectroscopy HPLC. enriched in (flavonoids, phenolic acids) showed a significant inhibition jack bean (over 90%), whereas case α-chymotrypsin, they proved an below 54%. results this support use as potential sources inhibitors. Among three tested, exhibited high (92.67%) low (19.6%) α-chymotrypsin could be considered possible remedy ulcer treatment.
sci-hub.se 参考文章(33)
Otto Isaac, Medicine containing the main sapogenin of helleborus ,(1975)
Vernon L. Singleton, Rudolf Orthofer, Rosa M. Lamuela-Raventós, ANALYSIS OF TOTAL PHENOLS AND OTHER OXIDATION SUBSTRATES AND ANTIOXIDANTS BY MEANS OF FOLIN-CIOCALTEU REAGENT Methods in Enzymology. ,vol. 299, pp. 152- 178 ,(1999) , 10.1016/S0076-6879(99)99017-1
Martin J. Blaser, Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation Gastroenterology. ,vol. 102, pp. 720- 727 ,(1992) , 10.1016/0016-5085(92)90126-J
KY Ee, J Zhao, A Rehman, S Agboola, None, Characterisation of trypsin and α-chymotrypsin inhibitors in Australian wattle seed (Acacia victoriae Bentham) Food Chemistry. ,vol. 107, pp. 337- 343 ,(2008) , 10.1016/J.FOODCHEM.2007.08.025
Zhu-Ping Xiao, Da-Hua Shi, Huan-Qiu Li, Li-Na Zhang, Chen Xu, Hai-Liang Zhu, None, Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease. Bioorganic & Medicinal Chemistry. ,vol. 15, pp. 3703- 3710 ,(2007) , 10.1016/J.BMC.2007.03.045
Harinder P S Makkar, Michael Blümmel, Norbert K Borowy, Klaus Becker, Gravimetric determination of tannins and their correlations with chemical and protein precipitation methods Journal of the Science of Food and Agriculture. ,vol. 61, pp. 161- 165 ,(1993) , 10.1002/JSFA.2740610205
Jin-Yuarn Lin, Ching-Yin Tang, DETERMINATION OF TOTAL PHENOLIC AND FLAVONOID CONTENTS IN SELECTED FRUITS AND VEGETABLES, AS WELL AS THEIR STIMULATORY EFFECTS ON MOUSE SPLENOCYTE PROLIFERATION Food Chemistry. ,vol. 101, pp. 140- 147 ,(2007) , 10.1016/J.FOODCHEM.2006.01.014
Shagufta Perveen, Azza Muhammed El-Shafae, Areej Al-Taweel, Ghada Ahmed Fawzy, Abdul Malik, Nighat Afza, Mehreen Latif, Lubna Iqbal, Antioxidant and urease inhibitory C-glycosylflavonoids from Celtis africana Journal of Asian Natural Products Research. ,vol. 13, pp. 799- 804 ,(2011) , 10.1080/10286020.2011.593171
H. P. S. Makkar, B. Singh, R. K. Dawra, Effect of tannin-rich leaves of oak (Quercus incana) on various microbial enzyme activities of the bovine rumen British Journal of Nutrition. ,vol. 60, pp. 287- 296 ,(1988) , 10.1079/BJN19880100
İlhan Gürbüz, Çiğdem Akyüz, Erdem Yeşilada, Bilge Şener, Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats. Journal of Ethnopharmacology. ,vol. 71, pp. 77- 82 ,(2000) , 10.1016/S0378-8741(99)00178-6