Honey as an apitherapic product: its inhibitory effect on urease and xanthine oxidase
作者： Huseyin Sahin
DOI: 10.3109/14756366.2015.1039532
关键词:
摘要: AbstractThe aim of this study was to evaluate new natural inhibitor sources for the enzymes urease and xanthine oxidase (XO). Chestnut, oak polyfloral honey extracts were used determine inhibition effects both enzymes. In addition investigate inhibition, antioxidant capacities these honeys determined using total phenolic content (TPC), ferric reducing power (FRAP), DPPH radical scavenging activity assays. Due their high content, chestnut are found be a powerful source Especially, efficient with 0.012–0.021 g/mL IC50 values, also XO 0.028–0.039 g/mL values. Regular daily consumption can prevent gastric ulcers deriving from Helicobacter pylori pathological disorders mediated by reactive oxygen species.
informahealthcare.com参考文章(41)
Xin Li, Harry L.T Mobley, Vaccines for Proteus mirabilis in urinary tract infection International Journal of Antimicrobial Agents. ,vol. 19, pp. 461- 465 ,(2002) , 10.1016/S0924-8579(02)00102-4
Luzia V. Modolo, Aline X. de Souza, Lívia P. Horta, Débora P. Araujo, Ângelo de Fátima, An overview on the potential of natural products as ureases inhibitors: A review Journal of Advanced Research. ,vol. 6, pp. 35- 44 ,(2015) , 10.1016/J.JARE.2014.09.001
M. W. Weatherburn, Phenol-hypochlorite reaction for determination of ammonia Analytical Chemistry. ,vol. 39, pp. 971- 974 ,(1967) , 10.1021/AC60252A045
Cinzia Nasuti, Rosita Gabbianelli, Giancarlo Falcioni, Franco Cantalamessa, Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats Nutrition Research. ,vol. 26, pp. 130- 137 ,(2006) , 10.1016/J.NUTRES.2006.02.007
Babasaheb P. Bandgar, Shivkumar S. Jalde, Balaji L. Korbad, Sachin A. Patil, Hemant V. Chavan, Santosh N. Kinkar, Laxman K. Adsul, Sadanand N. Shringare, Shivraj H. Nile, Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics. Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 27, pp. 267- 274 ,(2012) , 10.3109/14756366.2011.587416
Huseyin Sahin, Zehra Can, Oktay Yildiz, Sevgi Kolayli, Alessio Innocenti, Gabriele Scozzafava, Claudiu T. Supuran, Inhibition of carbonic anhydrase isozymes I and II with natural products extracted from plants, mushrooms and honey Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 27, pp. 395- 402 ,(2012) , 10.3109/14756366.2011.593176
H. Sahin, R. Aliyazicioglu, O. Yildiz, S. Kolayli, A. Innocenti, C. T. Supuran, Honey, polen, and propolis extracts show potent inhibitory activity against the zinc metalloenzyme carbonic anhydrase Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 26, pp. 440- 444 ,(2011) , 10.3109/14756366.2010.503610
Gabriela Paun, Simona Carmen Litescu, Elena Neagu, Andreia Tache, Gabriel Lucian Radu, Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and α-chymotrypsin Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 29, pp. 28- 34 ,(2014) , 10.3109/14756366.2012.749399
Yuan-Ching Chang, Fu-Wei Lee, Chien-Shu Chen, Sheng-Tung Huang, Shin-Hui Tsai, Shih-Hao Huang, Chun-Mao Lin, Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities. Free Radical Biology and Medicine. ,vol. 43, pp. 1541- 1551 ,(2007) , 10.1016/J.FREERADBIOMED.2007.08.018
Umeo Takahama, Yukiko Koga, Sachiko Hirota, Ryo Yamauchi, Inhibition of xanthine oxidase activity by an oxathiolanone derivative of quercetin. Food Chemistry. ,vol. 126, pp. 1808- 1811 ,(2011) , 10.1016/J.FOODCHEM.2010.12.009