Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics.
作者： Babasaheb P. Bandgar , Shivkumar S. Jalde , Balaji L. Korbad , Sachin A. Patil , Hemant V. Chavan
DOI: 10.3109/14756366.2011.587416
关键词:
摘要: Claisen-Schmidt condensation of 3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,5- trimethoxybenzaldehyde 3 and various aromatic, heterocyclic alicyclic amides 3- aminoacetophenone 6(a-s) afforded novel curcumin mimics. All the synthesized compounds were characterized by IR, (1)H NMR, Mass spectroscopy evaluated for antioxidant, cytotoxicity antimicrobial activity. Out 20 screened, 7i, 7l, 7q, 7n have shown excellent radical scavenging activity, 7o, 7t, 7f, 7r significant xanthine oxidase inhibition, 7a, 7k 7l found to be potent inhibitors selected cancer cell lines. Compounds 7h, 7e good antibacterial whereas 7j, 7t exhibited antifungal
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