Endothelium-derived nitric oxide: actions and properties.
作者： Louis J. Ignarro
DOI: 10.1096/FASEBJ.3.1.2642868
关键词:
摘要: Vascular smooth muscle relaxation in response to chemically diverse naturally occurring neurotransmitters and autacoids has been attributed the formation and/or release of one or more vascular endothelium-derived relaxing factors (EDRFs) distinct from prostacyclin. The chemical, biochemical, pharmacological properties such EDRF resemble closely nitric oxide (NO). Thus, both arterial venous EDRFs as well authentic NO cause heme-dependent activation soluble guanylate cyclase, endothelium-independent nonvascular accompanied by tissue cyclic GMP formation, inhibition platelet aggregation adhesion endothelial cell surfaces. artery, vein, freshly harvested cultured aortic cells was recently identified a labile nitroso species assessed chemical assay bioassay. Endothelium-derived (EDNO) an ultrashort half-life 3-5 s due spontaneous oxidation nitrite ni...
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