Polycystic ovary syndrome: pathophysiology, molecular aspects and clinical implications.

摘要: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age (5-10% prevalence) and the most cause anovulatory infertility. A recent consensus has led to formulation unifying diagnostic criteria for PCOS. It multifactorial polygenic nature. Although central pathogenesis PCOS, however neuroendocrine, ovarian metabolic dysfunctions play significant role pathophysiology. Short- long-term consequences have been focus much interest. The association PCOS with hyperandrogenism, hyperinsulinemia insulin resistance known some putative molecular aspects are established. Menstrual abnormalities (oligo- or amenorrhea), subfertility, obesity symptoms androgen excess often main reasons early referral, whereas diabetes, cardiovascular disease endometrial cancer represent clinical finding later life. plausible that appropriate specialist medical management improves wellbeing