Approaches Towards Avoiding Lifelong Antiretroviral Therapy in Paediatric HIV Infection

摘要: Paediatric HIV infection is a substantial global public health problem in its own right. Approximately one six new infections worldwide arises as result of mother-to-child transmission (MTCT). In contrast to adult infection, progression AIDS and death rapid most infected children cannot be satisfactorily predicted the youngest based on viral load or CD4 count. For this reason, current revised WHO guidelines recommending antiretroviral therapy (ART) initiated HIV-infected from birth, soon after birth possible, are fully justified. However, presents daunting challenge life-time ART, starting perinatal period. Given major difficulties maintaining adherence avoiding toxicity infancy through adolescence, it would seem imperative consider what alternative strategies ART may considered paediatric avoid prospect 10 years an epidemic adolescents failing salvage regimens. Furthermore, at rate growth, number living with will double within 5 years, cost together monitoring counts load, these numbers hard sustain. This review addresses, first, particular differences between immune responses effective control HIV, specific reference anti-HIV CD8+ T-cell response; and, second, interruption currently being explored that could provide lifelong for children.