Impact of MHC class I diversity on immune control of immunodeficiency virus replication

摘要: The outcome of HIV infection is strongly influenced by the particular HLA genes expressed infected individual. Here, authors draw on this association to evaluate what might constitute an effective CD8+T-cell response and how it guide vaccine design. recent failure T-cell-based trial led Merck & Co., Inc. prompts urgent need refocus question which T-cell responses are required control replication. well-described between expression MHC class I molecules successful containment or, in macaque model, SIV replication provide a valuable starting point from more precisely CD8+ responses. we review studies T-cell-mediated infection, offer insight for design future.