Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple Gag-specific CD8+ T-cell epitopes

摘要: To better understand relationships between CD8 + T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed role HLA-B*13, an allele associated with low viremia, in a cohort 578 C clade-infected individuals Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses 37 B*13-positive subjects, including three Gag epitopes. These contribute to broad Gag-specific response that is viremia. data are consistent studies other HLA-class I alleles HIV have shown targeting multiple relative suppression