Experience with Synthetic Vaccines for Cancer and Persistent Virus Infections in Nonhuman Primates and Patients

摘要: Synthetic vaccines, in particular long synthetic peptides of approximately 25-50 amino acids length, are attractive for HIV vaccine development and induction therapeutic immune responses patients with (pre-)malignant disorders. In the case preventive against HIV, no major success has been achieved, but possibilities by means exhausted. A peptide consisting 13 overlapping peptides, which together cover entire length two oncogenic proteins E6 E7 high-risk human papilloma virus type 16 (HPV16), caused complete regression all lesions eradication 9 out 20 women high-grade vulvar intraepithelial neoplasia, a therapy-resistant preneoplastic disorder. The nature strength vaccine-prompted T cell were significantly correlated clinical response. vaccines attractive, because they allow rational improvement design detailed pharmacokinetic pharmacodynamic studies not possible conventional vaccines. Improvements addition or conjugation adjuvants, notably TLR ligands, to peptides.