Enhancing the Solubility of Curcumin Using a Solid Dispersion System with Hydroxypropyl-β-Cyclodextrin Prepared by Grinding, Freeze-Drying, and Common Solvent Evaporation Methods.

摘要: Cyclodextrins (CDs) and their derivatives significantly increase drug solubility by forming drug/CD complexes known as solid dispersions (SDs), which consist of an inclusion complex (IC), where the is entrapped within CD cavity, a non-IC. Here, SDs curcumin (CUR) hydroxypropyl-β-cyclodextrin (HPβCD) were prepared using grinding, freeze-drying (FD), common solvent evaporation (CSE) methods physicochemically characterized solubility, powder X-ray diffraction, Fourier transform infrared, differential scanning calorimetry, dissolution studies. The second or higher order CUR-HPβCD indicated co-existence ICs non-ICs SD system. When comparing soluble amount with CUR crystals, was enhanced up to 299-, 180-, 489-fold, corresponding ground mixtures (GMs), (FDs), (CSEs), respectively. total transformation into amorphous phase observed in GMs CSE12, CSE14, CSE18. well dispersed HPβCD CSEs, suggesting formation hydrogen bonds between HPβCD, whereas behavior FDs similar that physical mixtures. In SDs, melting temperature increased 1:2 ICs, 1:1 crystals. rate positively improved increased. system consisting compared ICs.