Estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women but not in postmenopausal women

摘要: In the present study, we examined genotypes distribution of Pvu II estrogen receptor (ER) gene polymorphism and its association to bone mass in Thai females. Subjects consisted 134 females 54 whom were premenopausal 80 postmenopausal. ER was determined by PCR-RFLP. Capital P represents absence restriction site while small p indicates presence site. Forty nine (36.6%) subjects had pp genotype, 59 (44.0%) Pp genotype 26 (19.4%) PP genotype. There no significant difference age, body weight, height calcium intake women with different genotypes. The results including years since menopause similar postmenopausal women. When genotypes, dietary a stepwise multiple regression model, it found that besides weight associated mineral density (BMD) at AP spine (p < 0.05), lateral 0.05) femoral neck trochanter having least BMD. only factor BMD Ward's triangle, distal mid radius. serum intact osteocalcin (OC) concentrations among not related any skeletal Similarly, OC levels We concluded is but Estrogen may have modulatory role metabolism during adolescence young adulthood.