An assessment of genetic markers as predictors of bone turnover in healthy adults.

摘要: In 1992 a significant relationship between bone turnover and the vitamin D receptor (VDR) genotype was reported in Australian subjects of UK-Irish decent. Since then, several groups have investigated VDR other bone-related genotypes, mass populations. However, results these studies are conflicting. Therefore, our aim to determine genotypes population healthy Irish adults relate rate turnover. One hundred eighteen (aged 19–67 yr) were recruited fasting blood first void urines collected from each subject. Bone-related frequencies similar those Caucasian populations Hardy-Weinberg equilibrium. Estrogen (Pvu II or Xba I), apolipoprotein E collagen IA1 not related The tt associated with significantly higher serum osteocalcin (29% 40%) compared Tt TT respectively. ff urinary pyridinoline (by ∼44% ∼29%) deoxypyridinoline ∼76% ∼58%) levels ∼25% ∼53%) Ff FF These findings suggest that either rates than TT, respectively, therefore may risk low mineral density osteoporosis later life.