Genetic influence on bone turnover in postmenopausal twins

摘要: Postmenopausal bone mass is determined by both peak and subsequent loss. Previous studies have shown that under genetic influence mediated partly factors affecting formation. The rate of loss increases markedly after the menopause, but highly variable from subject to subject. aims this study were determine whether postmenopausal turnover was control, which should be linked on A classical twin performed compared intraclass correlations in monozygotic (MZ) twins with those dizygotic (DZ) twins, any difference assumed due factors. Markers formation resorption measured 240 untreated aged 45-69 yr, average 12.3 yr (SD, 6.0) postmenopause, including 61 MZ pairs 59 DZ pairs. correlation coefficient pairs, rMZ (95% confidence interval), for 2 specific markers formation, serum osteocalcin bone-specific alkaline phosphatase, higher than corresponding rDZ [0.67 (range, 0.59-0.75) vs. 0.48 0.35-0.61; P = 0.06) 0.53 0.41-0.65) 0.21 0.01-0.41; 0.02) phosphatase]. For propeptide type I collagen, a collagen synthesis marker exhibits only slight increase high proportion its variance explained [rMZ 0.82 (0.77-0.87), 0.33 (0.16-0.50); < 0.001]. three distinct urinary markers, total deoxypyridinoline two cross-linked peptides (CrossLaps NTX), menopause reached significance NTX (P 0.03). free dexoypyridinoline, reflecting degradation moderately significant 0.002). In conclusion, our data indicate levels are factors, contribution clearly do not change at menopause. These suggest overall possibly likely small.