Determinants of Peak Bone Mass Acquisition

摘要: Peak bone mass (PBM) is an important determinant of osteoporotic fracture risk later in life. Bone mineral accumulation from infancy to postpuberty a complex process implicating interactions genetic, endocrine, mechanical, and nutritional factors. PBM attained the axial skeleton proximal femur by end second decade The increase strength essentially due increment size, with volumetric density (BMD) changing very little during growth. In adult women, 10%, that is, approximately 1 standard deviation (SD), could decrease fragility 50% or be equivalent retarding menopause 14 years. growth follows trajectory. main influencing factor genetics. Increasing calcium intake mechanical loading can shift upward age-bone trajectory, while chronic diseases their treatment it downward. Prepuberty appears opportune time for obtaining substantial benefit increasing physical activity appropriate intakes proteins.