Outbreak of a West African recombinant of HIV-1 in Tashkent, Uzbekistan.
作者： Yuka Nadai , Nathan D. Wolfe , Deborah L. Birx , Kenneth C. Earhart , Jose L. Sanchez
DOI:
关键词:
摘要: Objectives: This research describes the genetic diversity of HIV-1 in Uzbekistan. Methods: During 2002 and 2003, blood from HIV-positive patients Uzbekistan was collected, part proviral pol gene nearly full-length genomes were sequenced analyzed. Results: Among 142 Uzbek strains, most clustered genetically with subtype A strain common former Soviet Union. Most these A-infected drug-naive subjects (65.6%) had an accessory drug resistance mutation, A62V, reverse transcriptase gene. Thirteen strains (9.2%) CRF02_AG, HIV West Africa. People infected CRF02_AG all residents Tashkent sampled 2002. The monophyletic probably descended a single ancestor. Two recombinant between A, each having different structure. elements recombinants A. New 12 suggested that neither nor this epidemic mosaics other subtypes or circulating forms. Conclusion: analysis demonstrated predominance epidemic. An outbreak African HIV-1, occurred Tashkent, 2002, however. cocirculation 2 has resulted new are apparently unique to
参考文章(25)
Robert W. Shafer, Duane R. Jung, Bradley J. Betts, Human immunodeficiency virus type 1 reverse transcriptase and protease mutation search engine for queries. Nature Medicine. ,vol. 6, pp. 1290- 1292 ,(2000) , 10.1038/81407
Alexei E. Masharsky, Nikolai A. Klimov, Andrei P. Kozlov, Molecular cloning and analysis of full-length genome of HIV type 1 strains prevalent in countries of the former Soviet Union. AIDS Research and Human Retroviruses. ,vol. 19, pp. 933- 939 ,(2003) , 10.1089/088922203322493139
VLADIMIR V LUKASHOV, EDWARD V KARAMOV, VLADIMIR F EREMIN, LEONID P TITOV, Jaap Goudsmit, None, Sequence Note: Extreme Founder Effect in an HIV Type 1 Subtype A Epidemic among Drug Users in Svetlogorsk, Belarus AIDS Research and Human Retroviruses. ,vol. 14, pp. 1299- 1303 ,(1998) , 10.1089/AID.1998.14.1299
MIKA O. SALMINEN, JEAN K. CARR, DONALD S. BURKE, FRANCINE E. McCUTCHAN, Identification of Breakpoints in Intergenotypic Recombinants of HIV Type 1 by Bootscanning AIDS Research and Human Retroviruses. ,vol. 11, pp. 1423- 1425 ,(1995) , 10.1089/AID.1995.11.1423
G I Mavrov, The evolution of sexually transmitted infections in the Ukraine Sexually Transmitted Infections. ,vol. 78, pp. 219- 221 ,(2002) , 10.1136/STI.78.3.219
STUART C. RAY, NDONGALA LUBAKI, BHARATI R. DHRUVA, ROBERT F. SILICIANO, ROBERT C. BOLLINGER, Autologous strain-specific cytolytic T lymphocyte responses directed against human immunodeficiency virus type 1 Env. AIDS Research and Human Retroviruses. ,vol. 14, pp. 3- 13 ,(1998) , 10.1089/AID.1998.14.3
Kirsi Liitsola, Irina Tashkinova, Tiina Laukkanen, Galina Korovina, Tatjana Smolskaja, Oleg Momot, Nikolai Mashkilleyson, Saulius Chaplinskas, Henrikki Brummer-Korvenkontio, Jussi Vanhatalo, Pauli Leinikki, Mika O. Salminen, HIV-1 genetic subtype A/B recombinant strain causing an explosive epidemic in injecting drug users in Kaliningrad. AIDS. ,vol. 12, pp. 1907- 1919 ,(1998) , 10.1097/00002030-199814000-00023
A. S. Perelson, A. U. Neumann, M. Markowitz, J. M. Leonard, D. D. Ho, HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time Science. ,vol. 271, pp. 1582- 1586 ,(1996) , 10.1126/SCIENCE.271.5255.1582
Andris Ferdats, Vera Konicheva, Iveta Dievberna, Elisabet Lilja, Jan Albert, None, An HIV type 1 subtype A outbreak among injecting drug users in Latvia. AIDS Research and Human Retroviruses. ,vol. 15, pp. 1487- 1490 ,(1999) , 10.1089/088922299310007
VLADIMIR A. NOVITSKY, MONTY A. MONTANO, MAX ESSEX, Molecular Epidemiology of an HIV-1 Subtype A Subcluster among Injection Drug Users in the Southern Ukraine AIDS Research and Human Retroviruses. ,vol. 14, pp. 1079- 1085 ,(1998) , 10.1089/AID.1998.14.1079